GUDMAP 1

GUDMAP 2

nGUDMAP

 

 

nGUDMAP Projects

Groups:

  • Gerard Ahern
  • Richard Baldock
  • Edinburgh Core Database
  • Sanjay Jain
  • Michelle Southard-Smith
  • Janet Keast
  • Gerard Ahern Group

    Nociceptive Innervation and Receptors in the Bladder - Bladder pain syndromes are common and especially prevalent in women. One of the problems in treating bladder pain is that our fundamental knowledge of nociceptive signaling in the bladder is limited. For example, nociceptive innervation in the bladder and the precise localization of key nociceptive receptors are not well defined. There is considerable controversy as to whether TRPV1, a major “pain” receptor, is expressed in non-neuronal tissues such as the bladder urothelium. Non-specific antibody labeling, and the preferential use of male rodents are major limitations of previous studies. The goal of this project is to exploit genetic models to precisely map the TRPV1-lineage and TRPV1 expression in male and female mouse bladders at different developmental stages. Further, we will confirm bona fide function of these channels in identified cells/tissue layers. At the conclusion we will be able to submit to GUDMAP the expression of the TRPV1 gene lineage and TRPV1 expression in bladder relative to specific tissue anchor genes... more

    Richard Baldock Group

    The primary purpose of the Nociceptive Genito-Urinary Developmental Anatomy (nGUDMAP) programme is to build a murine molecular anatomy atlas of the nociceptors (pain receptors) and associated cell types in pain processing of the urinary tract and pelvic region. In particular this will require the detailed description of the developmental origins, and the anatomical and biochemical heterogeneity of the murine nociceptors and associated cells. To do this, we propose to develop a spatiotemporal atlas of the developing neural connectome of the lower lumbar and pelvic region of the mouse during the critical developmental period when the neural connections... more

    Edinburgh Core Database Group

    The aim of nGUDMAP research projects is to generate data on the nociceptive systems associated with the urinary tract and pelvic region. This data will focus on the cells and molecular level detail of the neurons in the pelvic region. The main objective of the nGUDMAP Core Atlas Assembly Project is to support the nGUDMAP research projects. This involves extending the existing GUDMAP resource in specific aspects to capture the novel data-types.  More specifically, it will provide... more

    Sanjay Jain Group

    Pain is an essential defensive response in conditions such as acute cystitis that alert the host of an adverse insult.  However, in chronic conditions such as bladder pain syndrome (BPS) or overactive bladder, pathological neuronal and resultant pain is debilitating. Sensory afferents in the bladder emanate from sensory neurons in the dorsal root ganglia (DRG).  There is extensive heterogeneity in DRG at several levels including... more

    Michelle Southard-Smith Group

    The underlying cause of recurrent pain in the bladder, pelvis or urogenital floor that is a defining feature of pelvic pain disorders is not known. In other aspects of the nervous system, serotonin (5-HT) has been implicated in pain sensation and 5-HT increases in peripheral tissues with inflammation or thermal injury. Serotonin receptors (5-HTRs) can alter nociception by potentiating activity of the transient receptor potential V1 channel (Trpv1). Despite their known roles in nociception and effects on nociceptive channels like Trpv1 in other areas of the nervous system, there is a big knowledge gap about 5-HTRs in innervation of the urogenital system... more

    Janet Keast Group

    Pelvic pain conditions are debilitating and treatment options are limited. A major issue contributing to this problem is the relative lack of understanding of factors underlying persistent visceral pain conditions – a much larger research effort exists in the area of somatic pain (e.g., pain of skin, skeletal muscle, bone origin). The goal of this nGUDMAP molecular anatomy project is to map the primary structural and molecular features of a major population of nociceptor neurons that innervate the urinary bladder of the mouse...more