Tissue Summary: renal corpuscle (TS21-TS28)
renal corpuscle description
The renal corpuscle consists of a Bowman's capsule of parietal epithelium enclosing the glomerulus (glomerular tuft). The glomerulus is responsible for blood filtration and is composed of a tuft of capillaries whose endothelial cells are interconnected with specialized renal visceral epithelial cells, called podocytes and mesangial cells. The blood enters the capillaries via juxtaglomerular arterioles and glomerular filtrate is released into the Bowman's space and flows into the proximal renal tubule.
View renal corpuscle in GUDMAP Development Tutorials
In Situ Data
Validated Anchor/Marker Genes
Anchor genes are defined as genes whose expression is restricted to one temporospatial anatomical compartment. These have been selected by microarray analyses followed by validation using section in-situ hybridisation.
|Gene Symbol||Gene MGI ID||Anchor Of||Stage||Also Marker of||GUDMAP ID||Reference|
|C230096N06||capillary loop renal corpuscle (EMAPA:27770)maturing renal corpuscle (EMAPA:27943)||TS23||GUDMAP:13516||Thiagarajan et al. (2011)|
|Gpsm3||MGI:2146785||capillary loop renal corpuscle (EMAPA:27770)maturing renal corpuscle (EMAPA:27943)||TS23||GUDMAP:13584||Thiagarajan et al. (2011)|
|Tdrd5||MGI:2684949||maturing renal corpuscle (EMAPA:27943)visceral epithelium of maturing renal corpuscle (EMAPA:27967)||TS23||GUDMAP:9106||Thiagarajan et al. (2011)|
|Vip||MGI:98933||maturing renal corpuscle (EMAPA:27943)juxtaglomerular arteriole (EMAPA:27991)||TS23||GUDMAP:13795||Thiagarajan et al. (2011)|
Marker genes are defined as genes which display a regional or enriched expression pattern and may be useful in identifying one or more particular temporospatial compartment(s). These have been selected by microarray analyses followed by validation using section in-situ hybridisation.
Published genelists from Microarray Analysis. Click on the number of probes to go to heatmap view
|List Name||Description||Entities||Genes||Submitted By||Refs|
|Cortical Collecting Duct 15.5dpc||Brunskill et al.: Cortical Collecting Duct 15.5dpc||416 probesets||90||Bruce Aronow, Eric Brunskill||Brunskill et al. (2008)|
|K-means clustered - all from Brunskill et al. (2008)||Brunskill et al.: All k-means clustered probesets||7599 probesets||4757||Bruce Aronow, Eric Brunskill||Brunskill et al. (2008)|
|UQ Renal Corpuscle E15.5||Anchor genes specific to key renal compartments: Renal Corpuscle E15.5||9 probesets||8||Kylie Georgas, Rathi Thiagarajan||Thiagarajan et al. (2011)|
|Renal Corpuscle 15.5dpc||Brunskill et al.: Renal Corpuscle 15.5dpc||521 probesets||393||Bruce Aronow, Eric Brunskill||Brunskill et al. (2008)|
Non-published genelists from Microarray Analysis. Click on the list name or number of probes to go to heatmap view. Microarray Analysis Help.